Live extension. Longevity
Healthy lifestyle

A study of 2,270 rural Chinese health records found that an apparent link between physical activity and medication-field presence vanished once chronic-disease management registration was accounted for, exposing how documentation context can masquerade as a real association.

A seven-year study of over 14,000 Chinese adults finds that combining online and offline social activity is associated with slower cognitive decline and frailty progression in middle-aged and older people.

Frontiers in Neuroscience has retracted a 2018 study on microRNA Let-7f-5p and stem cell survival in Alzheimer's disease models after image integrity concerns and the authors' failure to provide complete raw data.

The journal Pathology & Oncology Research has retracted a 2018 osteosarcoma study after the authors reported improper image cropping, with an investigation confirming the findings are no longer supported by the data.

A new preprint links the company’s cell therapy to less brain inflammation in Alzheimer’s, just as it heads out on an investor tour. Longeveron went back to its Alzheimer’s data and took a second look. The Miami company’s CLEAR MIND trial, a Phase 2a study of 49 people, already reported its main results in Nature […] The post Longeveron’s stem cell data hint at calmer brains appeared first on Longevity.Technology.

A recently published study by University of New Mexico researchers looks at how intense exercise affects the body. Michael Deyhle, an associate professor in the Department of Health, Exercise and Sports Sciences, oversaw the study led by doctoral students Jonathan Specht, Jeremy Ducharme and Alyssa Bailly. The findings are published in the journal Physiological Reports.

On this week's “The Readout LOUD,” STAT's biotech podcast, we discuss the booming industry of longevity health.

In a study of fingertip regeneration, a team led by JAX senior research scientist James Godwin found that some immune cells in mice can attack and kill cells needed to rebuild bone, while a subset of those same immune cells can protect the bone-making cells and allow regeneration to continue.

A new GeroScience study shows that the dietary polyphenol chlorogenic acid protects aging intestinal stem cells from oxidative stress in fruit flies through a mechanism requiring CncC, the fly counterpart of the mammalian NRF2 pathway.

Scientists have uncovered a hidden biological mechanism that helps explain how exercise can reverse some of the damage caused by muscle aging. The key is a gene called DEAF1, which becomes overactive with age and interferes with the muscles’ ability to clear damaged proteins and repair themselves. Exercise can help restore this balance, allowing older muscles to rebuild and regain strength, although the benefits may diminish when the system becomes too disrupted.

Hungarian researchers have built a human induced pluripotent stem cell platform that reproduces the sensitivity of healthy dividing tissues to chemotherapy, revealing that stem cells and neural progenitors are far more vulnerable to anticancer drugs than conventional cancer cell lines suggest.

As major health systems open their own programs, longevity medicine is gaining credibility and becoming more accessible.

Li Renke, a visionary cardiovascular scientist who applied engineering principles to the human heart and developed conductive biomaterials to repair tissue damaged by heart attacks, died while attending an academic conference in the Chinese city of Xian earlier this month. He was 65. His death on October 10 was announced by The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), where he was presidential chair professor and associate dean of research and translation at the school of...

A new study reports that exosomes released by inflamed synovial stem cells carry the circular RNA circRNF20, which worsens rheumatoid arthritis by activating a TLR4, neutrophil trap, and interleukin-6 signaling pathway.

Jonathan the giant tortoise was born when Darwin was still a young man. Youthful gene activity may account for his exceptionally long life. The post The Oldest Living Land Animal Is 194. DNA May Now Reveal the Secret to His Longevity. appeared first on SingularityHub.

mTOR is a kinase that reads how many nutrients and how much energy a cell has, then decides whether that cell grows or repairs itself. That growth-versus-repair setting, and how it shifts with age, plays a role in several aging processes. mTOR is part of deregulated nutrient sensing, one of the 12 hallmarks of aging […] The post What Is mTOR? The Aging and Longevity Pathway first appeared on NOVOS.

Mount Sinai sent lab-grown heart and brain tissue models to the space station on SpaceX CRS-35 to study whether spaceflight speeds aging-like changes.

Animal studies suggest that the composition and activities of the gut microbiome are as influential on long-term health and the progression of degenerative aging as is the case for lifestyle choices such as degree of physical fitness and level of physical activity. The gut microbiome changes with age: microbial populations delivering harmful metabolites or that otherwise provoke the immune system into a state of chronic inflammation grow in number, while microbial populations delivering beneficial metabolites necessary for tissue function are reduced in number. Rejuvenation of the gut microbiome, which can be achieved via fecal microbiota transplantation from a young donor to old recipient, has been shown to improve health and extend life in aged animals. In the matters of health and aging, untangling the contribution […]

Exercise should be prescribed as a foundational component of cardiovascular disease (CVD) prevention and treatment, according to a new American College of Cardiology Scientific Statement published today in JACC, its flagship journal.

A new integrative review argues that exercise-related brain remodeling emerges from bidirectional brain-body crosstalk rather than a single peripheral factor, linking central motor commands, autonomic regulation, and cerebral hemodynamics with signal generation by skeletal muscle, liver, adipose tissue, bone, the gut microbiome, and the immune-vascular milieu.

Exercise should be prescribed as a foundational component of cardiovascular disease (CVD) prevention and treatment, according to a new American College of Cardiology scientific statement published in JACC.

Researchers examine whether alignment with the American Cancer Society lifestyle guidelines is linked to better physical health in breast cancer survivors, including those treated with chemotherapy.

Researchers here assess the present animal study evidence for first generation stem cell therapies to produce benefits in the most common neurodegenerative conditions, and also the consequences of stroke. The results are promising. While these therapies have been fairly widely deployed in patients via medical tourism, that data will never be available for analysis in any useful way. A few formal clinical trials have taken place, with unfortunately mixed results, which suggests that the details of manufacturing process, source of cells, and other logistical factors are important to outcomes. In general, these stem cell therapies appear to reliably modulate chronic inflammation, but all other desired outcomes are quite unreliable where they have been assessed rigorously in human patients. This is one of the reasons why […]

arXiv:2610.19782v1 Announce Type: new Abstract: Population health stratification frameworks, such as the Italian DM77, organize patients by clinical need and care pathways but offer limited guidance on which care changes to prioritize under constrained resources. We present PROMETHEUS (Proactive Resource Optimization through Multi-treatment Effect-based Targeting in Healthcare Environments Using Stratification), a framework that formulates population health stratification as a multi-treatment causal ranking problem. Its objective is to order eligible patient-treatment opportunities by expected incremental benefit rather than obtain perfectly calibrated individual treatment-effect estimates. Each clinically admissible care intensification is compared with maintaining the patient's current pathway. Treatments are learned jointly to produce a globally comparable ranking across patients and care profiles, within domains sharing a reference condition, outcome, follow-up horizon, and

Rapalogix Health announced the publication of a peer-reviewed, randomized, double-blind, vehicle-controlled 12-week study of RLX-201, the active molecule in Re-Q Longevity Face Serum, in the Journal of Cosmetic Dermatology. The trial was conducted at Dermatology Consulting Services in High Point, North Carolina, under principal investigator Zoe D. Draelos, MD, and enrolled 47 women aged 35 […] The post Rapalogix Health publishes clinical study on Re-Q Longevity serum appeared first on Longevity.Technology.

A cross-sectional study of 126 Sri Lankan adults found yoga practitioners had greater lower limb strength and flexibility while aerobic exercisers showed superior balance.

As we age, our bones become weak and brittle, a process called osteoporosis. This bone loss is caused by changes in the cells within the bone marrow microenvironment, such as elevated fat and inflammation-promoting immune cells. One molecular driver of inflammation is the STING signaling pathway, though the role of this pathway in aging bones has until now been unclear.

A cross-sectional study of 160 Turkish children found that higher adherence to the Mediterranean diet was independently associated with fewer cavities and healthier gums, while higher BMI was linked to poorer periodontal health.

A nationwide Taiwanese cohort study finds that older cancer survivors who return to work show significantly better long-term survival than those who do not, across all cancer stages.

Stem Cell Reports has been named the Official Meeting Journal of the ASSCR 2026 Annual Scientific Meeting, taking place 9-11 November 2026 in Melbourne, Australia.

Issues affecting ageing populations worldwide will form the core of discussions for policymakers and health industry leaders gathered at the Abu Dhabi Future Health Summit, with a particular emphasis on how practising prediction and prevention can help ensure life is lived to its fullest. The United Arab Emirates (UAE) has positioned itself as a global leader in transformative healthcare policy, and Dr Asma Al Mannaei, executive director of the health life science sector at the Department of...

Single-cell multiomics reveals that people who progress from ACPA-positive at-risk status to clinical rheumatoid arthritis carry an expansion of senescent-like activated naive B cells that express polyreactive autoreactive antibodies and present self-antigens to T cells.

Harvard-led researchers developed a transcriptomic aging clock to screen rejuvenation genes and found that over-expressing the RNA splicing factor SRSF1 reverses multiple hallmarks of aging in human cells and extends median lifespan in mice by 14 percent.

Creams, sprays and washes that promise relief from genital herpes are easy to order online, but none of them has been approved to treat the infection.

Researchers report that suppressing the lipid-metabolizing enzyme PLA2G7 in hippocampal neural stem cells restores inhibitory synapses and improves memory in aged mice.

Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified "hallmarks of aging" that not only present specific processes impacted by age, but are also thought of as levers that, if successfully targeted, could help turn back the aging clock and result in tissue rejuvenation.

WEDNESDAY, Oct. 14, 2026 — Creams, sprays and washes that promise relief from genital herpes are easy to order online, but none of them has been approved to treat the infection. The U.S. Food and Drug Administration (FDA) has sent warning...

Rima Kaddurah-Daouk of UTHealth Houston has received a five-year, $12 million National Institute on Aging grant to study how mitochondrial energy failure drives Alzheimer's disease and to develop precision strategies for maintaining brain health with age.

QIMA Life Sciences launches SQINGEVITY, bringing biological testing and clinical studies together to examine claims about skin and hair aging. For decades, the beauty industry sold younger-looking skin by the pot. Now it is being asked what those pots actually do – not to the reflection in the mirror, but to the cells. Longevity has […] The post Can cosmetics put longevity claims to the test? appeared first on Longevity.Technology.

A new Nature Metabolism study shows that NADH-reductive stress damages primary human cells mainly through NADPH depletion, and that a bacterial NAD kinase can restore proliferation and partially ease age-related liver inflammation in mice.

The data behind Blue Zones might not be that strong

A new meta-analysis of seven randomized controlled trials finds that vitamin D supplementation does not significantly alter circulating levels of the exercise-linked hormone irisin or the longevity-associated protein SIRT1, despite suggestive signals in small subgroups.

Since stem cell therapies produce beneficial effects via a short burst of signaling from the transplanted cells rather than via any long-lasting survival and engraftment of those cells, researchers are attempting to build therapies that deliver the signals instead of the cells. Manufacture involves culturing stem cells and harvesting the culture medium in order to obtain the molecules or extracellular vesicles secreted by the stem cells, and then introducing that material into patients. The signaling produced by different stem cell populations will likely prove to be more versus less useful in different contexts, and so some experimentation is needed. Here, researchers show that the secreted signals generated by dental pulp stem cells help to improve the outcome following stroke in mice. Ischemic stroke induces oxidative […]

Living longer and healthier is important. But don’t believe everything you hear.

A two-year study of 506 older adults in the COSMOS cohort found that plasma biomarkers of neurodegeneration, including NT1, NfL, and oAβ, largely failed to predict declines in walking speed, grip strength, and physical performance, with only changing NT1 levels tracking concurrent grip strength changes.

A new review in the Journal of Ovarian Research argues that age-related shifts in ovarian macrophages, driven by pathways such as cGAS-STING and NLRP3, may accelerate follicle depletion and could become targets for therapies that slow reproductive aging.

Experts discuss the draw of longevity clinics, potential risks, and how physicians can respond without abandoning evidence-based care.

A prospective study of 95,612 U.S. adults found that those with the highest sulfur microbial diet scores had a 23% higher adjusted lung cancer incidence hazard and a 19% higher lung cancer-related mortality hazard than those with the lowest scores. However, the associations weakened after accounting for overall dietary quality and competing causes of death, and the findings do not establish a causal relationship.

A study of 2,196 middle-aged and older Chinese adults found that meeting WHO physical activity guidelines was associated with a significantly lower atherosclerosis index and 25 percent lower odds of an adverse lipid profile.

VIB researchers have developed a new human stem-cell-based model that recreates an early stage of immune-cell development and shows how a single progenitor population can give rise to specialized macrophages across different organs. The model provides a platform to study how these processes change in disease, and how they might eventually be harnessed therapeutically.

Researchers used graphene oxide to restructure stem cell spheroids into multiple smaller aggregates, nearly doubling exosome yield and producing vesicles that accelerated vascularized wound healing in rats.

The world’s oldest land animal carries 287 unique gene variants involved in DNA repair and other defenses against aging, offering clues researchers hope to turn into human treatments. When Jonathan the giant tortoise hatched in 1832, Charles Darwin was still a young explorer and Queen Victoria had yet to take the throne. Nearly two centuries [...]

The age at which a woman experiences menopause and her reproductive history may be associated with how quickly she ages biologically, according to a study led by researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine).

The investment will expand continuous cover forestry across Europe, and represents SLM Silva Fund II's first and final close. The post SLM Partners secures $167m from Dutch pension investor to regenerate forests appeared first on AgFunderNews.

It is always good to see a diversification in non-profit efforts to advance the state of research and development in the matter of treating aging as a medical condition. Given the vast costs imposed by aging, humanitarian and fiscal, we stand a long way removed from the deployment of an adequate amount of funding for aging research. New advocates and new organizations are very welcome, to add to existing efforts to induce more funding for necessary research, and more capital into the longevity industry. We started Second Century Foundation to fulfill our childhood dream of a world where no one has to suffer or die from aging. Second Century Foundation is a 501(c)(3) private operating foundation focused on accelerating breakthroughs in human longevity. Much of […]

Cells become senescent in response to various forms of damage and stress, including the stress induced by reaching the Hayflick limit on replication. This was first described in the context of replicative senescence in cell cultures, and from there cellular senescence became a topic of interest in cancer research. In more recent years, the accumulation of senescent cells in aged tissues was demonstrated to be an important contribution to degenerative aging, and a small industry of biotech companies has emerged to develop a variety of therapies to either selectively destroy or modulate the behavior of senescent cells. The history of cellular senescence is, in many ways, a history of expanding biological complexity. What began as an observation of finite proliferative capacity in cultured cells has […]

Wiley has launched two open access journals, Advanced Medicine and Advanced Healthy Aging, expanding its Advanced Portfolio to more than thirty titles and extending its reach into translational medicine and aging science.

An NYU Abu Dhabi study in EMBO Reports shows that a single cancer-causing gene drives liver cells into distinct senescent states, some permanently tumor-suppressive and others reversible, with major implications for senolytic cancer therapy.

A study of more than 2,400 older adults finds that age-related hearing loss is linked to weaker structural brain connections, particularly between frontal and subcortical regions, supporting the sensory deprivation theory while pointing to cardiovascular health as a shared underlying cause.

Northwestern Medicine scientists have identified a stem-like state in small-cell lung cancer that distinguishes a group of patients with exceptionally poor outcomes following chemoimmunotherapy, according to a study published in Cell Reports Medicine.

In Aging Cell, a team of researchers has described how a little-known gene, ZNF865, has a significant influence on back pain through the regulation […]

A scoping review of 25 intervention trials finds that exercise is associated with modest improvements in depression and anxiety among male genitourinary cancer survivors, with evidence overwhelmingly concentrated in prostate cancer and no studies at all in penile cancer.

A Harvard-led study of more than 1,300 pregnancies found that a Mediterranean-style prenatal diet and regular seafood consumption were associated with significantly lower infant risk of colic and eczema.

Cells become senescent in response to stress and damage, in response to tissue injury, but most commonly upon reaching the Hayflick limit to replication. A senescent cell ceases to replicate, grows in size, and generates a potent mix of pro-growth, pro-inflammatory signals. Senescent cells are created throughout life in tissues throughout the body, but an established population of lingering senescent cells only begins to accumulate in later life. In youth, the immune system efficiently clears senescent cells, allowing senescence to be a beneficial state in the coordination of regeneration and in drawing the attention of the immune system to potentially cancerous cells. In later life, the immune system falters in this task. An established population of senescent cells that generates signaling constantly, even in relatively […]

A longitudinal study finds that older adults who recovered from COVID-19 mount weakened non-spike-specific Th1 CD4+ T cell responses to inactivated SARS-CoV-2 vaccines and Omicron breakthrough infection, revealing an age-related immune deficit that persists despite vaccination and reinfection.

Restore Hyper Wellness and Niagen Bioscience have launched a joint initiative declaring October as Longevity Month to emphasize healthspan over lifespan. The program pairs Restore, which the company describes as the nation’s largest provider of science-backed, personalized wellness therapies with more than 200 locations, with Niagen Bioscience, which the company claims is a leader in […] The post Restore, Niagen Bioscience launch Longevity Month to promote healthspan appeared first on Longevity.Technology.

After four weeks of using the cream, participants lowered the biological age of their skin by about two years on average.

Scientists discovered that declining levels of a protein called Menin may help drive aging, and restoring it in older mice reversed several age-related changes in just 30 days. Even more surprisingly, supplementing with a simple amino acid called D-serine improved memory and learning, offering a potential new approach to age-related cognitive decline.

An analysis of a clinical trial shows that 15% of adults with fecal incontinence had at least 75% fewer leakage episodes at both 1 and 3 months of an individualized diet, drug, and exercise plan.

A field study in China's Loess Hilly Region finds that mixed pine and black locust plantations are more stable than pure stands, but weak natural regeneration threatens their long-term persistence.

null

Sea cucumber tissue kept growing for more than three years after removal, surviving in seawater teeming with microbes. Like Thing, the disembodied hand in The Addams Family, a severed piece of sea cucumber tissue kept living without the body it came from, prompting scientists to describe the animal as a “real-life zombie.” Weeks after being [...]

University of Copenhagen researchers found that declining cardiolipin in mitochondria triggers an ERRγ-driven, ROS-mediated switch that trades muscle power for antioxidant protection, a process that may be druggable.

A gut bacteria-derived bile acid called hyodeoxycholic acid restores aging bone marrow stem cells and reverses bone loss in a mouse model of postmenopausal osteoporosis by activating a TGR5-ESR1 mitophagy pathway.

New cell research shows prolonged tadalafil exposure boosts proliferation of muscle progenitor cells, suppresses myostatin and TGF-beta, and delays terminal differentiation, suggesting therapeutic promise for muscle-wasting disorders while raising anti-doping concerns.

A detailed heat-treatment study shows how aging time controls nanoscale carbides, retained austenite and the strength-toughness balance in G53 ultra-high strength stainless steel.

A Vanderbilt-led team sequencing the genome and epigenome of Jonathan, a 194-year-old giant tortoise on St. Helena, found that promoters governing mitochondrial energy production retained youthful orderliness, suggesting that protecting gene regulation from entropy could extend the human healthspan.

A network meta-analysis of 16 randomized trials finds that combined physical-cognitive exercise is the most effective intervention for improving global cognition in older adults with mild cognitive impairment, followed by Tai Chi and coordination training.

Researchers adapted asphalt rheology methods to show that ageing of polymer-modified roofing bitumen compounds is driven by competing polymer degradation and binder stiffening, detectable with a single pressure-ageing cycle.

A new Aging Cell study shows that single-clock reports of biological age reversal often fail when tested against multiple epigenetic clocks, and proposes three criteria for distinguishing genuine aging signals from statistical noise.

New research in Cell Death Discovery shows that statins can induce senescence in liver cells, reducing circulating IGF-1 and triggering skeletal muscle atrophy through weakened AKT/mTOR signaling.

A dual-cohort study of hundreds of thousands of Israeli and American health records links severe vitamin D deficiency to elevated mortality and aging-related disease, while pharmacy-documented supplementation shows dose-dependent protective associations.

Critical Path Institute and the University of Arizona have launched a two-year collaboration using human stem cell-derived neurons and new approach methodologies to uncover the sex-specific cellular biology of Parkinson's disease in women.

Scientists engineered stem cell-derived vesicles to deliver tumor-suppressive miR-124 into colorectal cancer cells, silencing EZH2, weakening STAT3 signaling, and shrinking tumors in mice.

A new data-driven dietary index built around epigenetic aging clocks is associated with nearly four years slower biological aging, lower mortality, and reduced risk of age-related disease across large US and UK cohorts.

A new study in accelerated-aging mice shows that a neurogenesis-boosting compound rescues memory and hippocampal plasticity in males but not females, revealing fundamentally distinct neurogenic aging trajectories between the sexes.

A large ABCD Study analysis links social conditions such as pollution, school quality, unemployment, and discrimination to adolescent brain age gaps, with allostatic load mediating the effects and functional brain aging predicting depression two years later.

Using DXA data from nearly 29,000 Canadian adults, researchers have built the first age- and sex-specific percentile charts for the fat mass to fat-free mass ratio, a single metric that integrates obesity and sarcopenia into one measure of metabolic risk.

A Chonnam National University study found that the human dental pulp stem cell secretome reduced oxidative stress and neuroinflammation while restoring motor and cognitive function in a mouse model of ischemic stroke.

In general, people who eat a healthy diet give themselves a significantly better chance of avoiding some major diseases than those who don't. The Nordic diet, also known as a northern version of the Mediterranean diet, is a healthy, sustainable way of eating based on traditional foods of countries like Norway, Sweden, Denmark and Finland. It includes plant foods and berries, whole grains, low-fat dairy products and fatty fish.

Researchers have built vascularized, immune-integrated human skin assembloids from stem-cell-derived organoids that model atopic dermatitis-like inflammation and respond to approved drugs.

A Stanford study found that children and adults with Fontan circulation show shorter telomeres and signs of accelerated biological aging linked to poorer circulatory function and growing health burdens.

Preconditioning stem cells with a defined dose of 660 nm red light reprograms their mitochondria and activates a SOX9-driven chondrogenic program that substantially restores tracheal cartilage structure and mechanical function in rabbits.

New research in PLOS Biology shows that zebrafish embryos activate regeneration programs in response to genetic developmental defects, partially buffering the damage they cause.

A new Nature Communications study shows that age-driven upregulation of the translation regulator PPP1R15B, and declining levels of the microRNA miR-196a that restrains it, modify Huntington's disease progression across mouse and patient-derived neuron models.

A new GeroScience review details how failing mitochondria act as both initiators and amplifiers of cellular senescence and the chronic sterile inflammation known as inflammaging.

Researchers have discovered Δ246p53, a conserved 18-kilodalton p53 isoform translated from codon 246 that responds to DNA damage and enhances p53 family-driven senescence through interactions with full-length p53 and ΔNp63.

Gene therapies are used to treat many different blood disorders. However, blood stem cells often fail to achieve their full potential after transplantation.